Syllabus

Science Prerequisites for Health Professionals

BIOL 1055: Molecular Biology

Credits - 3

Description

This course will introduce and emphasize on the basic concepts of molecular biology and the application of these concepts in the medical field. The knowledge attained in the course will be used to understand human diseases. Topics include knowing about biomolecules like DNA, RNA and proteins, central dogma, DNA replication, DNA repair and regulation of gene expression. Each of these topics will be explored through course readings, video lectures, case studies, journal clubs, discussions forums and digital concept mapping. Students will demonstrate their knowledge of molecular biology concepts through quizzes and a cumulative final exam.

Materials

Textbooks

Molecular Biology of the Cell by Alberts, 6th edition. (Recommended Book)

Resources

Buttons and ribbons for Hands on DNA activity.

Mandatory UNE-approved webcam and whiteboard – To be used during proctored exams

Learning Objectives and Outcomes

Program Outcomes

In lecture courses, students should be able to:

  • Communicate scientific concepts and information clearly.
  • Illustrate fundamental laws, theories, and principles of scientific disciplines.
  • Apply knowledge and critical thinking skills to scientific problems.

Course Objectives

After completing this course, students will be able to:

  1. Describe the structure and function of biomolecules like DNA, RNA and proteins.
  2. Illustrate how the information flows from DNA to RNA to proteins in prokaryotic and eukaryotic system.
  3. Explain how alterations/ mutations at genetic level affect proteins and causes human disease.
  4. Describe and illustrate the significance of DNA replication process for cell division.
  5. Explain the importance of fidelity of the process of DNA replication.
  6. Identify the protein machinery involved in DNA replication process in prokaryotes and eukaryotes.
  7. Describe the involvement of DNA repair mechanisms in response to the effect of DNA mismatch and DNA damage both in prokaryotic and eukaryotic system.
  8. Discuss different kinds of genetic recombination processes and their significance.
  9. Describe and illustrate regulation of gene expression at different levels in both prokaryotic and eukaryotic system.
  10. Describe how molecular biology techniques like PCR, sequencing, microarrays, DNA fingerprinting and CRISPR etc.are used in the medical field.

SELF PACED DESIGN

On the course start date, students will have access to orientation. This must be completed to be able to gain access to the first module in the course. Students must complete the first module to gain access to the next one. We recommend that students spend about 15 hours per week to complete a course in 16 weeks. When trying to complete the course in less than 16 weeks, we typically see students do this successfully within 12-14 weeks. Instructors will be timely in grading and feedback, but it will not be instant.

Assignments

The assignments will include weekly quizzes and 4 tests. Before taking quizzes and tests students can get an experience by making use of provided practice questions. There are assignments associated with weekly online activities which include Ted Talks, case studies, concept maps, discussion forums, journal club and virtual lab. At the end of the course there will be a proctored final exam. The duration of exam is 30 minutes and no resources will be allowed during the exam.

This Final Exam must be taken through ProctorU. See UNE’s ProctorU page for information about signing up and scheduling your exam. The official UNE webcam is required.

Proctored exams are closed for review. You will not be able to review them at any time. Please contact your instructor for specific feedback.

Grading Policy

Your grade in this course will be determined by the following criteria:

Grade Breakdown

Quizzes420 points
Tests225 points
Activities (Concept Mapping, Case Studies, Ted Talk Reflections, Journal Club, Virtual Lab, DNA hands-on activity)255 points
Final Exam100 points
Total1,000 points

Schedule

Week

Topic

Readings/Resources

Assignments

1

DNA and RNA

Chapter 4

Supplemental Material

Videos

TED Talk Reflection

Online DNA activity

Hands-on DNA model activity

Quiz

2

Proteins

Chapter 3

Supplemental Material

Videos

TED Talk Reflection

Homology Modeling

Game Foldit

Quiz

3

Central Dogma: Fundamentals

Chapter 6

Supplemental Material

Videos

Central Dogma Online Activity

Genetic Code Discussion

Quiz

4

Central Dogma: Transcription

Chapter 6

Supplemental Material

Videos

 

 

Quiz

 

 

5

Central Dogma: Translation

Chapter 6

Supplemental Material

Videos

TED Talk Reflection

Concept Map

Quiz

6

Mutations

Chapter 23

Supplemental Material

Videos

TED Talk Reflection

Gleevec Case Study

Test

7

DNA Replication: Overview

Chapter 17

Supplemental Material

Videos

Online Interphase Matching Activity

Quiz

8

Fidelity of Replication

Chapter 5

Supplemental Material

Videos

TED Talk Reflection

Discussion Forum

Test

9

DNA Replication

Chapter 5

Supplemental Material

Videos

TED Talk Reflection

Concept Map

Quiz

10

DNA Replication

Chapter 5

Supplemental Material

Videos

TED Talk Reflection

Case Study

Quiz

11

DNA Repair

Chapter 5

 Videos

TED Talk Reflection

Case Study

Quiz

12

DNA Recombination

Chapter 5

 Videos

Concept Map

Test

13

Regulation of Gene Expression

Chapter 7

 

Videos

Concept Map

Quiz

14

Regulation of Gene Expression

Chapter 7

 

Videos

TED Talk Reflection

Journal Club

Quiz

15

Molecular Biology Techniques

Material provided

Videos

Ted Talk

Microarray virtual lab

Quiz

16

Finals Week

 

Test 4

Final Exam

Student Resources

Student Portal: Your Best UNE Resource

We created the UNE Online Student Portal, specifically for you, to be a useful collection of information to support you as you navigate your online course(s).

From the UNE Online Student Portal, you can access:

  • Blackboard/Brightspace
  • Technical Support
  • Library
  • Bookstore
  • UNE Email
  • U-Online

The portal also features:

  • Dates to Remember
  • Support and Services
  • Contact information for your Support Specialist
  • Academic Resources - links to the Academic Calendar, Registrar and Academic Calendar
  • Financial - links to eBilling, Financial Aid and Student Accounts

Instructor and Support Contact Information

Check Blackboard/Brightspace for specific instructor and support specialist contact information.

Further Assistance

Your student service advisor monitors course progression and provides assistance or guidance when needed. They can assist questions regarding ordering course materials, University policies, billing, navigating the course in Blackboard/Brightspace, and more.

Student Lounge

The Student Lounge Discussion Board is a designated support forum in which students may engage with each other and grapple with course content. Feel free to post questions, seek clarification, and support each other, but be mindful of UNE's Academic Integrity Policy.

Your instructor will monitor this forum. However, if you are seeking specific and timely answers to questions about course content or your personal grades, please contact your instructor via course messages. For questions about course materials, program policy, and how to navigate and proceed through the course, please contact your Student Service Advisor through the Student Portal.

Policies

Proctored Examinations

The University of New England has contracted with ProctorU to provide students with the most convenient online exam proctoring system. This system provides a simple, no cost to the student, secure, online proctor for exams and allows the student to take all the exams at home and on their own schedule.

Upon enrollment into the course, each student will register with ProctorU and establish a login name and password. This will give the student access to all of ProctorU's services. When ready, students will schedule each of their proctored exams with ProctorU. Exams must be scheduled at least 72 hours in advance to avoid fees. Prior to taking their exams, students must be sure that they have downloaded the ProctorU Chrome or Firefox extension and are using the most current version of Chrome or Firefox. They must also be sure their testing site's connection meets the minimum requirements by using ProctorU's "Test It Out" utility.

Upon the exam day and hour, students will log in to ProctorU and click on "exams". After following the procedures outlined at ProctorU's web site, the student will log in to Blackboard/Brightspace and locate their correct exam. The proctor will then allow student access to that exam.

Students must use ProctorU and must follow all proctoring requirements for their exams to be credited.

Proctored exams are not available for review at any time. You will not be able to see the questions, nor the answers you've given, after completing the exams. Please contact your instructor for specific feedback.

Course Discussions

Discussion board assignments cover interesting current events or materials related to this course that contribute to a deeper understanding of key concepts and allow you to interact with your classmates and the instructor. Each assignment may require you to conduct internet research, read additional materials (a short journal or magazine article), visit a specific webpage, AND/OR view a short video prior to writing a response following the specific guidelines in the assignment.

To earn full credit: you will need to post a response to the discussion topic, respond to the original posts of at least two other students, and then contribute meaningfully to an ongoing discussion. You will need to post your initial response before you will see any posts from your classmates. Please keep in mind that only this initial response is included in your assignment grade, so make sure you have followed all of the guidelines and written a complete response prior to submitting the post. For special cases where one or two students are accelerating faster through the course, the instructor will participate in the discussion so that everyone has the opportunity to interact.

Please see Blackboard/Brightspace for a full description, along with specific guidelines, for each assignment. Discussion board assignments should be completed, along with all other assignments in the course, in the order that they appear. Due to the course design, you may be unable to take a proctored exam if you do not complete all assignments that appear prior to that exam.

Please also refer to the Grading Policy/Grade Breakdown section of the syllabus to learn the percentage of your grade that each discussion board assignment is worth.

Technology Requirements

Please review the technical requirements for UNE Online Graduate Programs: https://online.une.edu/online-learning/technical-requirements/

Course Length

A schedule of lectures and assignments is included in this syllabus. This is, however a self-paced course and you can complete the course in less time.

  1. Courses in the SPHP program are equivalent to one-semester courses designed to be completed in 16 weeks
  2. Enrollment in the course begins the day your section opens which is listed in the Academic Calendar found on the Student Success Portal.
  3. Course start and end dates are in respect to Eastern Time.

Withdrawal and Refund Policies

Please visit this page to review the withdrawal and refund policies.

Grade Policy

Students are expected to attempt and complete all graded assignments and proctored exams by the end date of the course. To view the incomplete grade policy, please click here.

Transcripts

Due to the Family Educational Rights and Privacy Act, only the student may request official transcripts. This may be done online by going to the University of New England Registrar website and following the directions on the page.

To view your unofficial UNE student transcript:

  1. Log into uonline at https://uonline.une.edu
  2. Select Student Services
  3. Select Student Records
  4. Select Academic Transcript

To request your official UNE student transcript:

Please review your Unofficial Transcript prior to requesting an Official Transcript.

  1. Log into uonline at https://uonline.une.edu
  2. Select Student Services
  3. Select Student Records
  4. Select Request Printed/Official Transcript
  5. Follow the prompts

After you click Submit Request, your official transcript will be put into the queue to be printed in the Registrar’s Office.

Academic Integrity

The University of New England values academic integrity in all aspects of the educational experience. Academic dishonesty in any form undermines this standard and devalues the original contributions of others. It is the responsibility of all members of the University community to actively uphold the integrity of the academy; failure to act, for any reason, is not acceptable.

Academic dishonesty includes, but is not limited to the following:

  1. Cheating, copying, or the offering or receiving of unauthorized assistance or information.
  2. Fabrication or falsification of data, results, or sources for papers or reports.
  3. Action which destroys or alters the work of another student.
  4. Multiple submission of the same paper or report for assignments in more than one course without permission of each instructor.
  5. Plagiarism, the appropriation of records, research, materials, ideas, or the language of other persons or writers and the submission of them as one's own.

Charges of academic dishonesty will be reviewed by the Program Director. Penalties for students found responsible for violations may depend upon the seriousness and circumstances of the violation, the degree of premeditation involved, and/or the student’s previous record of violations. Appeal of a decision may be made to the Dean whose decision will be final. Student appeals will take place through the grievance process outlined in the student handbook.