Syllabus

Science Prerequisites for Health Professionals

BIOL 1040 Genetics

Credits - 4

Description

This course covers important concepts of genetics like the transmission and expression of genes. Both Mendelian and non-Mendelian traits will be examined. One of the important topics covered in this course will focus on the influence of genetic mutations on the development of disease, like cancer. The critical role chromosomes play in genetics will be emphasized through the study of cellular reproduction, gene-mapping on chromosomes, the effect of chromosomal variation on disease, and the study of both the autosomal and sex chromosomes. Students will learn from examples drawn from the scientific literature, which stress modern technological and experimental methodologies used in studying the genetics and genomics of various prokaryotes and eukaryotes as well as bacteriophages. Topic presentations will also reflect the fundamental role genetic mechanisms play in the pathogenesis, treatment, and health maintenance of genetic diseases.

Prerequisite: General Biology I

Materials

Required Textbook

Klug WS, Cummings MR, Spencer CA, Palladino MA. Concepts of Genetics. 12th ed. Pearson; 2019. ISBN-13: 978-0134604718

Required Lab Materials

To complete the laboratory component of this course, students are directed to purchase the following lab materials:

  • Hands on Labs (HOL) Kit
    • The kit must be purchased through HOL and cannot be purchased second hand or from another vendor.
    • Kits can take 5 – 7 business days to arrive.
    • For help ordering your HOL Kit, please follow the “Getting Started with Hands On Labs” guide located on the HOL link in Blackboard.
    • The HOL policy on Returns and Refunds will be viewable prior to completing your order.
    • HOL lab kits: For customer service concerns, please use the HOL dedicated phone line (720-360-4034).
  • Labster Virtual Labs
    • Detailed instructions for purchasing access and the instructor course code are located on the Labster Virtual Labs link in Blackboard.

Mandatory Official UNE-approved external webcam and whiteboard – To be used during proctored Exams

Dry-Erase Whiteboard with Marker and Eraser for Proctored Exams. This course permits the use of a UNE authorized dry-erase whiteboard for scratch work during your proctored midterm and final exam. No scratch paper is permitted. The whiteboard must be purchased from the UNE authorized seller. Please note there is a discount if your order both the webcam and the whiteboard together. Choose “Whiteboard and Webcam Combo”.

Learning Objectives and Outcomes

Learning Outcomes for Science Prerequisites for Health Professions Program

In lecture courses, students should be able to:

  1. Communicate scientific concepts and information clearly.
  2. Illustrate fundamental laws, theories, and principles of scientific disciplines.
  3. Apply knowledge and critical thinking skills to scientific problems.

In lab courses, students should be able to:

  1. Ask a question or define a problem that can be tested.
  2. Hypothesize possible result(s).
  3. Plan and/or conduct an investigation individually and/or collaboratively to produce data to serve as the basis for evidence.
  4. Analyze data using tools, technologies, and/or models (i.e. computational, mathematical, graphical, etc.) in order to make valid and reliable scientific claims or determine an optimal design solution.
  5. Communicate the results by constructing an explanation based on multiple pieces of valid and reliable evidence obtained from a variety of sources (including students’ own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future.
  6. Apply scientific ideas, principles, and/or evidence gained from various experiments, as well as other observations and/or research, to provide an explanation of phenomena and solve design problems, taking into account possible unanticipated effects.

Course Outcomes

Upon completion of this course, students will be able to:

1. Define the terms associated with cellular reproduction, Mendelian genetics, non-Mendelian genetics, cancer genetics, population/evolutionary genetics, extranuclear inheritance, gene mapping, DNA organization, DNA duplication, gene expression, gene regulation, gene mutation/repair, epigenetics, chromosomal sex determination, and chromosomal variation.

2. Summarize the principles of cellular reproduction, Mendelian genetics, non-Mendelian genetics, cancer genetics, population/evolutionary genetics, extranuclear inheritance, gene mapping, DNA organization, DNA duplication, gene expression, gene regulation, gene mutation/repair, epigenetics, chromosomal sex determination, and chromosomal variation.

3. Interpret the processes of cellular reproduction, Mendelian genetics, non-Mendelian genetics, cancer genetics, population/evolutionary genetics, extranuclear inheritance, gene mapping, DNA organization, DNA duplication, gene expression, gene regulation, gene mutation/repair, epigenetics, chromosomal sex determination, and chromosomal variation.

4. Explain the central dogma of biology in detail with a thorough description of the structure and function of DNA, RNA, and proteins and mechanisms of transcription and translation along with their regulation.

5. Describe the unique features and properties of bacterial and phage genetics.

6. Construct genetic maps for physical locations of loci with respect to one another using data from recombination frequencies, three­-point testcrosses, or molecular markers.

7. Examine how chromosomal changes lead to genetic disease and the interplay between genetics and manifestation of cancer.

8. Synthesize primary literature from the field of genetics.

9. Assess genetic data using the scientific method.

Assignments

Refer to the Grade Breakdown diagram and table below for the percent value of assignments towards your total grade. See the course schedule below for where assignments occur in the course. All assignments should be completed in the order that they appear. Due to the course design, you may be unable to take a proctored exam if you do not complete all assignments that appear prior to that exam.

Discussion Board Posts

Discussion board assignments cover interesting current events or materials related to this course that contribute to a deeper understanding of key concepts and allow you to interact with your classmates and the instructor. Each assignment may require you to conduct internet research, read additional materials (a short journal or magazine article), visit a specific webpage, AND/OR view a short video prior to writing a response following the specific guidelines in the assignment.

To Earn Full Credit: you will need to post an initial response to the discussion topic (200-300 words in length formatted in AMA style for in-text citations and references), respond to the original posts of at least two other students, and then contribute meaningfully to an ongoing discussion. You will need to post your initial response before you will see any posts from your classmates. Please keep in mind that only this first post will be graded as your initial post, so make sure you have followed all of the guidelines and written a complete response prior to submitting the post. Any edits or subsequent posts will not be graded as your initial post. 

For special cases where one or two students are accelerating faster through the course, the instructor will participate in the discussion so that everyone has the opportunity to interact.

Please see Blackboard for a full description and rubric, along with specific guidelines, for each assignment. See the course schedule below for where discussions occur in the course. Discussion board assignments should be completed, along with all other assignments in the course, in the order that they appear. Due to the course design, you may be unable to take a proctored exam if you do not complete all assignments that appear prior to that exam.

Video Presentations

There are 4 video presentation assignments in this course. Refer to the presentation assignments on Blackboard for the full requirements of each presentation and links to resources on how to prepare your presentations. Also, refer to the presentation assignment rubric in My Grades in Blackboard for grading requirements. Please note you must begin each video presentation by showing yourself full-screen, looking directly into the camera, and clearly stating your full name while holding up a piece of paper on which your full name is printed in large, bold letters, and the date of the presentation.
Video recordings without the required identification will not be accepted.

See the course schedule below for where presentations occur in the course. Presentation assignments should be completed, along with all other assignments in the course, in the order that they appear. Due to the course design, you may be unable to take a proctored exam if you do not complete all assignments that appear prior to that exam.

Case Study

There is one Case Study assignment in the course. Your instructor will provide a list of topics for you to choose from to complete your Case Study assignment. Refer to the Case Study assignment instructions on Blackboard for the full assignment requirements. Also, refer to the case study rubric in My Grades on Blackboard to help you prepare an effective case study.

Laboratory Assignments

This course uses a combination of at-home lab kits, lab activities using an online lab platform, lab activities using a virtual lab platform, and lab exercises built on Blackboard for active experiential learning of genetic concepts. See the course schedule below for lab assignments.

For Hands on Labs and Labster assignments, you will be completing those assignments as directed using the online platforms provided by the two lab companies. Your instructor will have a course set-up in each for you to complete your work. Once you complete the lab assignments, you will use the text submission field for the assignment in Blackboard to write a message to your instructor. This will serve as an alert to your instructor that your assignment is ready to be reviewed and graded.

Lab Report

There is one lab report assignment. The lab report will be based on the Extraction of DNA Lab completed in Unit 3. Refer to the Lab Report assignment instructions on Blackboard for the full assignment requirements. Also, refer to the Lab Report rubric in My Grades on Blackboard to help you prepare an effective lab report.

Weekly Quizzes

The weekly quiz will cover the content and learning outcomes assigned for that particular week including lab content. The quizzes are timed and could include multiple-choice, multiple-answers, and matching questions. Refer to each quiz in Blackboard for specific instructions. The quizzes are not proctored.

Proctored Exams

There are two proctored exams. The University of New England has contracted with ProctorU to provide students with the most convenient online exam proctoring system. Upon enrollment into the course, you will register with ProctorU and establish a login name and password. This will give you access to all of ProctorU’s services.

When you’re ready, you will schedule your exam time with ProctorU at least 72 hours prior to taking the exam. Please refer to the full requirements for proctored exams in the Policies section below.

Midterm Exam: Will cover the content and learning outcomes studied during weeks 1 to 7 (units 1 and 2), including the lab content.

Final Exam: Will cover all the content studied throughout the entire course, including the lab content. The exam will predominantly (80%) cover the content and learning outcomes from weeks 9 to 15 (units 3 and 4). The rest of the exam (20%) will cover the content and learning outcomes covered during the first half of the course (units 1 and 2).

The midterm and final exams are closed book, closed notes. You may only use a UNE-authorized whiteboard to work out problems during the exam. Both exams are timed and include multiple-choice, multiple-answer, matching, and essay questions. A list of possible essay topics for each exam is included in the study guides provided on Blackboard. These exams are also closed for review. You will not be able to review these exams at any time. You may contact your instructor for specific feedback on your exam.

You must purchase the Official UNE External Webcam to take your proctored examinations. Remember to order your webcam at least three weeks prior to scheduling your first proctored exam.

Grade Breakdown Diagram

Grading Policy

Your grade in this course will be determined by the following criteria:

Grade Breakdown

AssignmentsPercent of Total Grade
Lecture Grade Assignments:
Weekly Quizzes10%
Discussions and Presentations15%
Case Study20%
Midterm Exam25%
Final Exam30%
Total100%
Laboratory Grade Assignments:
Lab Activities (HOL, Labster)80%
Lab Report20%
Total100%
Final Course Grade (Weighted Total):
Lecture Grade75% of Lecture Grade
Lab Grade25% of Laboratory Grade
Total Course Grade100%

Grade Scale

Grade Points Grade Point Average (GPA)
A 94 – 100% 4.00
A- 90 – 93% 3.75
B+ 87 – 89% 3.50
B 84 – 86% 3.00
B- 80 – 83% 2.75
C+ 77 – 79% 2.50
C 74 – 76% 2.00
C- 70 – 73% 1.75
D 64 – 69% 1.00
F 00 – 63% 0.00

Schedule

This is a 16 week, self-paced course. Learning modules are organized by weeks as a guide for completing the course in the required timeframe. Your pace for learning and completing weekly assignments may vary. All learning modules are set to open sequentially after the previous module learning activities are completed. If you don’t see the next module in the sequence, it means you have not completed all the previous module activities.

You must complete the SPHP New Student Orientation in Getting Started on the left navigation menu in Blackboard, including the Scavenger Hunt and Academic Integrity Agreement first to access the lab purchasing instructions and Unit 1. 

Unit 1

Week 1 Topics:
Intro to Genetics (Chapter 1)
Mitosis & Meiosis (Chapter 2)

Week 1 Lab Activities:
Hands On Labs –
 Getting Started,
Lab Safety, and
Using the V-Scope
Week 1 Assignments:
Intro Video Recording
Intro Discussion Post
Unit 1 Discussion Post
Week 1 Quiz
Week 2 Topic: 
Mendelian Genetics
(Chapter 3)

Week 2 Lab Activities:
Hands On Labs –
Mitosis and Meiosis

Week 2 Assignments:
Week 2 Quiz
Week 3 Topic: 
Extensions of Mendelian Genetics (Chapter 4)

Week 3 Lab Activities:
Hands On Labs –
Genetics and Genomics

Week 3 Assignments:
Unit 1 Presentation
(Applied Genetics)
Week 3 Quiz
Week 4 Topic: 
Extranuclear Inheritance (Chapter 9)
Week 4 Exercise
(Blackboard)
Week 4 Assignments:
Week 4 Exercise
Week 4 Quiz
Unit 2

Week 5 Topics: 
Chromosome Mapping in Eukaryotes
(Chapter 5),
Sex Determination and Sex Chromosomes
(Sections 7.1, 7.2, and 7.4), 
DNA Organization in Chromosomes (Section 12.4)

Week 5 Lab Activities:
Labster Virtual Labs –
Medical Genetics
Week 5 Assignments:
Unit 2 Presentation
(Mapping Demo)
Week 5 Quiz
Week 6 Topic: 
Chromosomal Mutations: Variation in Number and Arrangement (Chapter 8)
Week 6 Lab Activities:
Hands on Labs –
Human Genetics
Week 6 Assignments:
Unit 2 Discussion
Week 6 Quiz

Week 7 Topics: 
Genetic Analysis and Mapping in Bacteria and Bacteriophages
(Chapter 6)
DNA Organization in Chromosomes (Section 12.1)
Special Topics in Modern Genetics 1 CRISPR-Cas and Genome Editing

Week 7 Lab Activities:
Labster Virtual Labs –
CRISPR-Cas applied to TGF-beta induced EMT

Week 7 Assignments:
Week 7 Quiz
Week 8 Topic:
Study for Midterm Exam
Week 8 Lab Activities:
No lab assignment this week.
Week 8 Assignments:
Proctored Midterm Exam
Unit 3 Week 9 Topic:
DNA Structure and Analysis
(Chapter 10)
Week 9 Lab Activities:
Hands on Labs –
Extraction of DNA and
Lab Report
Week 9 Assignments:
Unit 3 Discussion
Lab Report
Week 9 Quiz
Week 10 Topic:
DNA Replication
and Recombination
(Chapter 11)
Week 10 DNA Replication Exercise
(Blackboard)
Week 10 Assignments:
Week 10 Exercise
Week 10 Quiz
Week 11 Topics:
The Genetic Code and Transcription (Chapter 13), Translation and Proteins (Chapter 14)
Week 11 Lab Activities: 
Hands on Labs –
DNA, RNA, and Protein Synthesis
Week 11 Assignments:
Unit 3 Presentation
(Beyond the Genetic Code)
Week 11 Quiz
Week 12 Topics:
Gene Regulation (Chapter 16 sections 1, 2, and 5; Chapter 17 sections 1, 2, 3, 4, and 5; Chapter 18 sections 1, 2, 3, and 5)
Week 12 Lab Activities: 
Labster Virtual Labs –
Gene Regulation
Week 12 Assignments:
Week 12 Quiz
Unit 4 Week 13 Topics:
Gene Mutation, DNA Repair, and Transposition
(Chapter 15)
Week 13 Lab Activities: 
Labster Virtual Labs-
Animal Genetics
Week 13 Assignments:
Unit 4 Presentation
(Gene Therapy)
Week 13 Quiz
Week 14 Topics:
Cancer Genetics (Chapter 24),
Epigenetics (Chapter 19 sections 1, 2, 3, and 4)
Week 14 Lab Activities: 
Hands on Labs –
Aging and Disease
Week 14 Assignments:
Unit 4 Discussion
Week 14 Quiz
Week 15 Topics:
Population and
Evolutionary Genetics (Chapter 26)
Week 15 Lab Activities: 
Hands on Labs –
Populatoin Genetics and Evolution
Week 15 Assignments:
Case Study Due
Week 15 Quiz
Week 16 Topic:
Study for Final Exam
Week 16 Lab Activities:
No lab assignment this week.
Week 16 Assignments:
Proctored Final Exam

Student Resources

Student Portal: Your Best UNE Resource

We created the UNE Online Student Portal, specifically for you, to be a useful collection of information to support you as you navigate your online course(s).

From the UNE Online Student Portal, you can access:

  • Blackboard
  • Technical Support
  • Library
  • Bookstore
  • UNE Email
  • U-Online

The portal also features:

  • Dates to Remember
  • Support and Services
  • Contact information for your Support Specialist
  • Academic Resources - links to the Academic Calendar, Registrar and Academic Calendar
  • Financial - links to eBilling, Financial Aid and Student Accounts

Instructor and Support Contact Information

Check the course welcome page in Blackboard for specific instructor and support specialist contact information.

Further Assistance

Your student service advisor monitors course progression and provides assistance or guidance when needed. They can assist questions regarding ordering course materials, University policies, billing, navigating the course in Blackboard, and more.

Student Lounge

The Student Lounge Discussion Board is a designated support forum in which students may engage with each other and grapple with course content. Feel free to post questions, seek clarification, and support each other, but be mindful of UNE’s Academic Integrity Policy.

Your instructor will monitor this forum. However, if you are seeking specific and timely answers to questions about course content or your personal grades, please contact your instructor via course messages. For questions about course materials, program policy, and how to navigate and proceed through the course, please contact your Student Service Advisor through the Student Portal.

Accommodations

Any student who would like to request, or ask any questions regarding, academic adjustments or accommodations must contact the Student Access Center at (207) 221-4438 or pcstudentaccess@une.edu. Student Access Center staff will evaluate the student's documentation and determine eligibility of accommodation(s) through the Student Access Center registration procedure.

Policies

Proctored Examinations

The University of New England has contracted with ProctorU to provide students with the most convenient online exam proctoring system. This system provides a simple, no cost to the student, secure, online proctor for exams and allows the student to take all the exams at home and on their own schedule.

Upon enrollment into the course, each student will register with ProctorU and establish a login name and password. This will give the student access to all of ProctorU’s services. When ready, students will schedule each of their proctored exams with ProctorU. Exams must be scheduled at least 72 hours in advance to avoid fees. Prior to taking their exams, students must be sure that they have downloaded the ProctorU Chrome or Firefox extension and are using the most current version of Chrome or Firefox. They must also be sure their testing site’s connection meets the minimum requirements by using ProctorU’s “Test It Out” utility.

Upon the exam day and hour, students will log in to ProctorU and click on “exams”. After following the procedures outlined at ProctorU’s web site, the student will log in to Blackboard and locate their correct exam. The proctor will then allow student access to that exam.

Students must use ProctorU and must follow all proctoring requirements for their exams to be credited.

Proctored exams are not available for review at any time. You will not be able to see the questions, nor the answers you've given, after completing the exams. Please contact your instructor for specific feedback.

Course Discussions

Discussion board assignments cover interesting current events or materials related to this course that contribute to a deeper understanding of key concepts and allow you to interact with your classmates and the instructor. Each assignment may require you to conduct internet research, read additional materials (a short journal or magazine article), visit a specific webpage, AND/OR view a short video prior to writing a response following the specific guidelines in the assignment.

To earn full credit: you will need to post a response to the discussion topic, respond to the original posts of at least two other students, and then contribute meaningfully to an ongoing discussion. You will need to post your initial response before you will see any posts from your classmates. Please keep in mind that only this initial response is included in your assignment grade, so make sure you have followed all of the guidelines and written a complete response prior to submitting the post. For special cases where one or two students are accelerating faster through the course, the instructor will participate in the discussion so that everyone has the opportunity to interact.

Please see Blackboard for a full description, along with specific guidelines, for each assignment. Discussion board assignments should be completed, along with all other assignments in the course, in the order that they appear. Due to the course design, you may be unable to take a proctored exam if you do not complete all assignments that appear prior to that exam.

Please also refer to the Grading Policy/Grade Breakdown section of the syllabus to learn the percentage of your grade that each discussion board assignment is worth.

Technology Requirements

Please review the technical requirements for UNE Online Graduate Programs: https://online.une.edu/online-learning/technical-requirements/

Course Length

A schedule of lectures and assignments is included in this syllabus. This is, however a self-paced course and you can complete the course in less time.

  1. Courses in the SPHP program are equivalent to one-semester courses designed to be completed in 16 weeks
  2. Enrollment in the course begins the day your section opens which is listed in the Academic Calendar found on the Student Success Portal.
  3. Course start and end dates are in respect to Eastern Time.

Withdrawal and Refund Policies

Please visit this page to review the withdrawal and refund policies.

Grade Policy

Students are expected to attempt and complete all graded assignments and proctored exams by the end date of the course. To view the incomplete grade policy, please click here.

Transcripts

Due to the Family Educational Rights and Privacy Act, only the student may request official transcripts. This may be done online by going to the University of New England Registrar website and following the directions on the page.

To view your unofficial UNE student transcript:

  1. Log into uonline at https://uonline.une.edu
  2. Select Student Services
  3. Select Student Records
  4. Select Academic Transcript

To request your official UNE student transcript:

Please review your Unofficial Transcript prior to requesting an Official Transcript.

  1. Log into uonline at https://uonline.une.edu
  2. Select Student Services
  3. Select Student Records
  4. Select Request Printed/Official Transcript
  5. Follow the prompts

After you click Submit Request, your official transcript will be put into the queue to be printed in the Registrar’s Office.

Academic Integrity

The University of New England values academic integrity in all aspects of the educational experience. Academic dishonesty in any form undermines this standard and devalues the original contributions of others. It is the responsibility of all members of the University community to actively uphold the integrity of the academy; failure to act, for any reason, is not acceptable.

Academic dishonesty includes, but is not limited to the following:

  1. Cheating, copying, or the offering or receiving of unauthorized assistance or information.
  2. Fabrication or falsification of data, results, or sources for papers or reports.
  3. Action which destroys or alters the work of another student.
  4. Multiple submission of the same paper or report for assignments in more than one course without permission of each instructor.
  5. Plagiarism, the appropriation of records, research, materials, ideas, or the language of other persons or writers and the submission of them as one's own.

Charges of academic dishonesty will be reviewed by the Program Director. Penalties for students found responsible for violations may depend upon the seriousness and circumstances of the violation, the degree of premeditation involved, and/or the student’s previous record of violations. Appeal of a decision may be made to the Dean whose decision will be final. Student appeals will take place through the grievance process outlined in the student handbook.

Late Policy

Assignments: Late assignments will be accepted up to 3 days late; however, there is a 10% grade reduction (from the total points) for the late submission. After three days the assignment will not be accepted.

Discussion posts: If the initial post is submitted late, but still within the discussion board week, there will be a 10% grade reduction from the total discussion grade (e.g., a 3 point discussion will be reduced by 0.3 points). Any posts submitted after the end of the Discussion Board week will not be graded.

Please make every effort ahead of time to contact your instructor and your student support specialist if you are not able to meet an assignment deadline. Arrangements for extenuating circumstances may be considered by faculty.

Student Handbook Online - Policies and Procedures

The policies contained within this document apply to all students in the College of Graduate and Professional Studies.   It is each student’s responsibility to know the contents of this handbook.

http://success.une.edu/eBooks/CGPS-Student-Handbook/

UNE Course Withdrawal

Please contact your student support specialist if you are considering dropping or withdrawing from a course. The last day to drop for 100% tuition refund is the 2nd day of the course. Financial Aid charges may still apply. Students using Financial Aid should contact the Financial Aid Office prior to withdrawing from a course.

Academic Integrity

The University of New England values academic integrity in all aspects of the educational experience. Academic dishonesty in any form undermines this standard and devalues the original contributions of others. It is the responsibility of all members of the University community to actively uphold the integrity of the academy; failure to act, for any reason, is not acceptable. For information about plagiarism and academic misconduct, please visit https://www.une.edu/studentlife/plagiarism.

Academic dishonesty includes, but is not limited to the following:

  1. Cheating, copying, or the offering or receiving of unauthorized assistance or information.
  2. Fabrication or falsification of data, results, or sources for papers or reports.
  3. Action which destroys or alters the work of another student.
  4. Multiple submissions of the same paper or report for assignments in more than one course without permission of each instructor.
  5. Plagiarism, the appropriation of records, research, materials, ideas, or the language of other persons or writers and the submission of them as one's own.

Charges of academic dishonesty will be reviewed by the Program Director. Penalties for students found responsible for violations may depend upon the seriousness and circumstances of the violation, the degree of premeditation involved, and/or the student’s previous record of violations.  Appeal of a decision may be made to the Dean whose decision will be final.  Student appeals will take place through the grievance process outlined in the student handbook.