Syllabus

Science Prerequisites for Health Professionals

BIOL 1030: Pathophysiology: Mechanisms of Diseases – Spring 2020

Credits - 4

Description

Pathophysiology is the study of disordered physiological processes associated with disease.

This course is an introduction to pathophysiology designed especially to meet the needs of students preparing for careers in the health professions – for example, Physician Assistant, Pharmacy,  Medicine, Nursing, and Dental Hygiene.

This course focuses on the changes in cellular and systemic physiology that occur in prevalent or important medical conditions. At the cellular level we will cover the responses to tissue injury, abnormal cell growth and the immune system. From there we will investigate the physiological basis of problems associated with most of the major organ systems. In each case we will discuss the effect upon whole body homeostasis. This course will build on prior knowledge of anatomy and physiology as we explore body functions in altered health conditions. The primary teaching methods will be online video lectures with slides, textbook reading, and online assessments, supplemented with multi-media resources including interactive tutorials and animations.

Materials

  • Grossman SP, C. Porth’s Pathophysiology: Concepts of altered health states. 9th ed. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2014.
    • NOTE: The recently released 10th edition has differently organized chapters. If you are using the 10th edition, use this table to recognize what readings are required week by week.

 

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Learning Objectives and Outcomes

Program Outcomes

In lecture courses, students should be able to:

  1. Communicate scientific concepts and information clearly.
  2. Illustrate fundamental laws, theories, and principles of scientific disciplines.
  3. Apply knowledge and critical thinking skills to scientific problems.

Course Objectives

Upon successful completion of the course, students will be able to:

  • Explain the concept, classification, etiology of disease states and imbalances. 

  • Analyze how health deviations alter normal physiology. 

  • Describe the alterations in cells, tissues, and organs that occur with disease and how they affect the body functions.
  • Describe the clinical manifestations of diseases and the most commonly used tests and procedures to diagnose them. 

  • Discuss the most frequent complications of diseases and their prognoses.
  • Set the pathophysiological foundation for treatments.  

SELF PACED DESIGN

On the course start date, students will have access to orientation. This must be completed to be able to gain access to the first module in the course. Students must complete the first module to gain access to the next one. We recommend that students spend about 15 hours per week to complete a course in 16 weeks. When trying to complete the course in less than 16 weeks, we typically see students do this successfully within 12-14 weeks. Instructors will be timely in grading and feedback, but it will not be instant.

Assignments

Lectures and Assignments

This course requires the following prerequisite prior to registering for the course: Successful completion of Anatomy and Physiology (200 level preferred) or equivalent with permission of the instructors.

Students are expected to log in at least three times a week for the entire course. All required assignments and assessments will be posted inside the UNE Blackboard course module. Each module will have learning objectives, lectures, assigned reading, online activities, and self assessments, followed by a weekly quiz. 

Examination and Grading Information  

Midterm and Final Exam

Exams will be taken through ProctorU (see “Policies” below), and will consist of approximately 50 multiple-choice type questions (each) with seventy-five minutes (each) allowed for completion. The Midterm exam covers material from Weeks 1-7; the final exam covers Weeks 9-15. These tests are closed book and no notes or resources are permitted. Back-tracking is permitted on these exams. No re-takes are allowed, except under extraordinary conditions (e.g., documented technical problem).

For all exams, you must review the Proctored Examinations information and requirements in the Policies section of this syllabus. You must purchase the Official UNE External Webcam to take your proctored examinations. Remember to order your webcam at least three weeks prior to scheduling your first proctored exam.

These exams are closed for review. You will not be able to review them at any time. Please contact your instructor for specific feedback.

14 Weekly Quizzes

The quiz for each week (except Weeks 8 and 16) will consist of approximately 10 multiple-choice and multiple-answer type questions. Quizzes will be taken through Blackboard, and may be taken open book, but will be timed, with fifteen minutes allowed for completion and no backtracking.

3 Student Presentations

There are three recorded presentations required in the course, due in Weeks 2, 9 and 15.

For Weeks 2 and 9, you will be asked to record 5-minute presentations, without using slides, in which you need to exhibit deep enough understanding of specified concepts and terms to explain those concepts and terms orally. Please go to the course week in which each is due and refer to the detailed assignment instructions.

In Week 15, you will be asked to record a presentation, without using slides, on a disease of your own choosing. You will need to research the disease and describe certain details about the syndrome in your presentation—see detailed instructions for a list of assignment requirements.

Case Studies / Quizzes

There are 6 Case Studies with associated quizzes in the course. These case studies portray a patient-provider care situation, and you will be prompted to answer Matching questions using details from the case studies to inform your answers.

Discussions

There are several discussions in the course, in which you will be expected to draw from the course material, and sometimes material from outside the course, in order to post and participate.

 

Grading Policy

Your grade in this course will be determined by the following criteria:

Grade Breakdown

AssignmentPercentage Grade Value
Weekly Quizzes (14, each worth 1% of the final grade)14%
Case Studies (6, each worth 2% of the final grade)12%
Discussions (5, each worth 1.2% of the final grade)6%
Student Presentations (3, worth 4%, 4% and 5% of the final grade)13%
Dissection Labs (4, each worth 2.5% of the final grade)10%
Midterm20%
Final25%
Total100%

Grade Scale

Grade Points Grade Point Average (GPA)
A 94 – 100% 4.00
A- 90 – 93% 3.75
B+ 87 – 89% 3.50
B 84 – 86% 3.00
B- 80 – 83% 2.75
C+ 77 – 79% 2.50
C 74 – 76% 2.00
C- 70 – 73% 1.75
D 64 – 69% 1.00
F 00 – 63% 0.00

Schedule

Course Outline

This course is designed to be completed in a 16-week period, which breaks down to one module per week for 14 weeks and two exam weeks (midterm and final). One week in this online course is equivalent to 200 minutes of lecture in a traditional classroom setting. The general rule of studying for science courses is to spend 3 hours studying for every hour that you are in class. Therefore, the suggested study time for each module is 12 hours above and beyond the time it takes to listen to the lecture. Please refer to the schedule below for the order of topics.

Weeks Topics and Notable Assignments Text Readings**
1

Health and Disease, Stress and Adaptation

  • Discussion: What is Pathophysiology?
  • Week 1 Case Study
  • Week 1 Quiz
Chapters 1 and 9
2

Cellular Adaptation, Injury, and Death. Neoplasia.

  • Short Video Presentation – Basic Concepts
  • Week 2 Case Study
  • Week 2 Quiz
Chapters 5 and 8
3

Mechanisms of Infectious Diseases. Innate and Adaptive Immunity. Inflammation, Tissue Repair, and Wound Healing. Disorders of the Immune Response.

  • Week 3 Case Study
  • Week 3 Quiz
Chapters 12, 13, 14, 15 and 16
4

Disorders of Motor Function. Disorders of Brain Function. Disorders of memory.

  • Sheep Brain Dissection
  • Week 4 Quiz
Chapters 19, 20 and 22
5

Disorders of Visual Function. Disorders of hearing and Vestibular Function.

  • Dissection of Cow Eye
  • Week 5 Quiz
Chapters 23 and 24
6

Disorders of the hemostasis. Disorders of Red Blood Cells. Disorders of White Blood Cells and Lymphoid Tissues

  • Discussion: Homeostasis
  • Week 6 Quiz
Chapters 26, 27 and 28
7

Disorders of blood flow in the systemic circulation. Disorders of blood pressure regulation. Disorders of cardiac Function. Disorders of cardiac conduction and rhythm. Heart failure and circulatory shock.

  • Dissection of Sheep’s Heart
  • Week 7 Quiz
Chapters 30, 31, 32, 33, 34
8

MIDTERM EXAM

  • Discussion: Etiology of disease
 
9

Respiratory tract Infections, neoplasms, and childhood disorders. Disorders of ventilation and gas exchange.

  • Short Video Presentation – Syndrome
  • Week 9 Quiz
Chapters 36 and 37
10

Disorders of fluids and electrolyte balance. Disorders of Acid-Base balance. Disorders of renal function. Acute renal injury and chronic kidney disease. Disorders of the bladder and urinary tract.

  • Dissection of Sheep’s Kidney
  • Week 10 Quiz
Chapters 39, 40, 41, 42 and 43
11

Disorders of the gastrointestinal function. Disorders of hepatobiliary and exocrine pancreas function.

  • Week 11 Case Study
  • Week 11 Quiz
Chapters 45 and 46
12

Disorders of endocrine control of growth and metabolism. Diabetes mellitus and the metabolic syndrome.

  • Discussion: The Endocrine System
  • Week 12 Quiz
Chapters 49 and 50
13

Disorders of the male genitourinary system. Disorders of the female genitourinary system.

  • Week 13 Case Study
  • Week 13 Quiz
Chapters 52 and 54
14

Disorders of the musculoskeletal function: Trauma, Infection, Neoplasms, Developmental and metabolic disorders, Rheumatic disorders.

  • Week 14 Case Study
  • Week 14 Quiz
Chapters 57, 58 and 59
15

Disorders of skin integrity and function.

  • Short Video Presentation – Final Presentation on Disease of Choice
  • Week 15 Quiz
Chapter 61
16

FINAL EXAM

  • Discussion – Reflection on concept of pathophysiology
 

** Please go to individual weeks in Blackboard for detailed instructions.

Student Resources

Instructor and Support Contact Information

Contact: Contact via Blackboard course messaging system. It will help us track messages better and get back to you promptly.

Office hours: by appointment

Further Assistance:

Your student support specialist monitors course progression and provides assistance or guidance when needed. They can assist questions regarding ordering course materials, University policies, billing, navigating the course in Blackboard, and more.

Accommodations

Any student who would like to request, or ask any questions regarding, academic adjustments or accommodations must contact the Student Access Center at (207) 221-4438 or pcstudentaccess@une.edu. Student Access Center staff will evaluate the student's documentation and determine eligibility of accommodation(s) through the Student Access Center registration procedure.

Online Student Support

Your Student Support Specialist is a resource for you. Please don't hesitate to contact them for assistance, including, but not limited to course planning, current problems or issues in a course, technology concerns, or personal emergencies.

Questions? Visit the Student Support Science Prerequisites page

Instructor and Support Contact Information

Check Brightspace for specific instructor and support specialist contact information.

Further Assistance

Your student service advisor monitors course progression and provides assistance or guidance when needed. They can assist questions regarding ordering course materials, University policies, billing, navigating the course in Brightspace, and more.

Student Lounge

The Student Lounge Discussion Board is a designated support forum in which students may engage with each other and grapple with course content. Feel free to post questions, seek clarification, and support each other, but be mindful of UNE's Academic Integrity Policy.

Your instructor will monitor this forum. However, if you are seeking specific and timely answers to questions about course content or your personal grades, please contact your instructor via course messages. For questions about course materials, program policy, and how to navigate and proceed through the course, please contact your Student Service Advisor through the Student Portal.

Policies

Online Student Support

Your Student Support Specialist is a resource for you. Please don't hesitate to contact them for assistance, including, but not limited to course planning, current problems or issues in a course, technology concerns, or personal emergencies.

Questions? Visit the Student Support Science Prerequisites page

Instructor and Support Contact Information

Check Brightspace for specific instructor and support specialist contact information.

Further Assistance

Your student service advisor monitors course progression and provides assistance or guidance when needed. They can assist questions regarding ordering course materials, University policies, billing, navigating the course in Brightspace, and more.

Student Lounge

The Student Lounge Discussion Board is a designated support forum in which students may engage with each other and grapple with course content. Feel free to post questions, seek clarification, and support each other, but be mindful of UNE's Academic Integrity Policy.

Your instructor will monitor this forum. However, if you are seeking specific and timely answers to questions about course content or your personal grades, please contact your instructor via course messages. For questions about course materials, program policy, and how to navigate and proceed through the course, please contact your Student Service Advisor through the Student Portal.