Syllabus

Master of Science in Applied Nutrition

APN 510: Applied Nutrition Biochemistry

Credits - 3

Description

Using human nutrition as a model, this biochemistry focused course will explore metabolic pathways to which macro and micronutrients play a significant regulatory role, as well as the interaction between nutrients within these pathways. The course is guided by the exploration of recent scientific literature in areas of nutrition and biochemistry and ways one informs the other. Topics include energetics of metabolism; structure and metabolism of macro and micronutrients; and the integration of metabolic systems. Students will examine signs and symptoms of nutrient deficiency as well as excess, and understand nutrition status with respect to disease prevention and therapy through an emphasis on biochemical mechanisms of nutrition and metabolism.

 

Materials

Required:

  • Gropper SS, Carr TP. Advanced Nutrition and Human Metabolism. 9th ed. Cengage Learning; 2027.

Optional:

  • Drug Nutrition Interactions subscription is an optional resource.
    • If you elect to purchase it, select the Student Plan and use the code UNE202608555 at checkout for a discounted rate.

Learning Objectives and Outcomes

ACEND Competencies:

Unit 1

1.1 Apply foundational sciences and knowledge in food and nutrition. (S)

  • 1.1.1 Describe nutrient metabolism, including the integration and regulation of macro- and micro-nutrition. (K)
  • 1.1.2 Apply organic chemistry and biochemistry knowledge to make informed food and nutrition decisions for medical nutrition therapy and optimal health. (S)
  • 1.1.4 Integrate knowledge of molecular factors, including genes, proteins, and metabolites, in the development and management of disease. (K)

1.2 Apply knowledge of pharmacology and pharmacokinetics to recommend, prescribe, and administer medical nutrition therapy. (K)

  • 1.2.1 Identify the classifications of nutraceutical and pharmacological agents and their actions on the body. (K)
  • 1.2.2 Apply knowledge of classifications, categories, and indications for commonly used medications and supplements (for example, weight management, hypertension, diuretics, cardiovascular disease, diabetes). (K)
  • 1.2.3 Demonstrate understanding of pharmacokinetics as it applies to medications and supplements. (K)

1.3 Apply an understanding of the impact of integrative and functional nutrition on disease, health, and wellness. (S)

  • 1.3.1 Explain how nutrients and nutrition supplements influence disease, physical activity, and wellness. (K)

1.4 Integrate research methods and principles into evidence-based practice. (S)

  • 1.4.3 Evaluate research to support evidence-based decision-making and draw valid conclusions. (S)

Unit 3

3.1 Apply critical thinking to make ethical and evidence-based decisions. (S)

  • 3.1.1 Make decisions based on evidence-based practice and ethical principles. (S)
  • 3.1.2 Define the problem and determine steps for resolution. (S)

Unit 4

4.2 Conduct a nutrition assessment to inform the nutrition diagnosis. (S)

  • 4.2.3 Recognize pertinent laboratory values and their impact on health and nutrition. (S)
  • 4.2.6 Identify signs and symptoms of malnutrition and nutrient deficiencies and excesses. (S)
  • 4.2.7 Assess individual energy and nutrient needs based on physiology and health status. (S)
  • 4.2.8 Recognize and communicate the causes of disease and nutritional risks. (K)

Course Outcomes

  • Discuss the relationship between human metabolism, micronutrients and macronutrients and how systems are integrated to maintain health
  • Examine biochemical pathways that are relevant to an understanding of normal and disordered nutrition processes
  • Critically analyze and evaluate mechanisms of nutrition and metabolism that are important for an understanding of biochemistry as it relates to human nutrition and nutrition care processes
  • Apply scientific research findings to explain the biochemical mechanisms underlying health and disease states

Assignments

Quizzes

Your coursework will include quizzes, with the exception of Week 8. Each quiz has 15 multiple-choice questions based on the week’s Gropper textbook reading. You have one attempt and a 120-minute time limit, and quizzes are due Tuesday at 11:59 PM ET. You must complete the quiz within one sitting, so do not start the quiz until you have enough time and are prepared to finish it.

Discussion Board

You will be required to participate in discussions. Initial posts are due on Sundays, and responses are due by Tuesday, with the exception of Week 8, in which the initial post is due by Friday and no responses are required. In Week 1, the initial post is a 3–5 minute video, followed by one response.

If the required posts are not submitted within the discussion week, you will be given a zero. Posts submitted after the discussion week will not be graded.

Your success in the course relies on robust discussion, critical thinking, and peer response. Weekly posts responding to prompts posed are meant to facilitate a deeper understanding of the broader themes of the course as well as enrich the readings, handouts, and lectures. Your initial response should be no less than 400 words unless otherwise specified. Peer responses should be no less than 200 words unless otherwise specified and must be thoughtful, contain compliments as well as constructive criticism, and maintain a professional tone. Posts should include citations, and AI is not to be used in discussion boards.

Assignments

In Weeks 1–7, your coursework will include a Clinical Reasoning Presentation. After completing the week’s reading and reviewing the Morning Report video and Patient Case EMR, you will record a 5–8 minute video explaining the biochemical mechanisms behind a de-identified teaching patient’s presentation, supported by a slide deck with an AMA-formatted reference slide. You will submit your video and slides on the assignment page for grading. In Week 8, you will instead submit a written Course Reflection of at least 400 words.

Writing Statement

As professionals in the field, you will consistently be expected to clearly and concisely articulate advanced concepts for diverse audiences at a variety of educational levels.

Graduate students are expected to integrate and apply current scientific evidence and scholarly practice guidelines when completing assignments. Theories, ideas, concepts, and other information obtained or generated through review of the scholarly literature must be synthesized and summarized across multiple sources and correctly attributed.

Graduate students are expected to produce work that is their own and that is their best quality work. Students are expected to screen and proofread their work prior to submission for proper attribution of sources and authority, clarity, grammar, spelling, formatting, and mechanical issues.




While there is often a portion of each assignment’s rubric dedicated specifically to grammar, spelling, mechanics, and formatting, it is critical to understand that failure to submit work that has been adequately proofed may result in a reduction of points in other areas of the rubric. These may include, but are not limited to metrics rating professionalism or content knowledge and synthesis; work submitted in graduate courses should provide evidence of strategic reading, writing, and academic speaking skills essential for success in the discipline.

Please note that the Graduate Programs in Applied Nutrition, which includes the Doctor of Clinical Nutrition program, holds the position that Grammarly and other artificial intelligence (AI) writing and generative technology should not be used when completing course assignments, unless explicitly permitted by course faculty and assignment instructions. These tools do not support a student’s personal and direct capacity to develop and hone skills in creativity, logic, critical thinking, analysis, evaluation, theorization, and writing, which are central to graduate level rigor, assessment, and research. Use of these tools may result in an academic integrity infraction.

Grading Policy

Your grade in this course will be determined by the following criteria:

Grade Breakdown

Assignment: Point Value:
Student Syllabus Contract 2
Weekly Discussions (8 @ 4 points each) 32
Clinical Reasoning Presentations (Weeks 1-7 @ 6 points each)42
Quizzes (Weeks 1-7 @ 3 points each)21
Course Reflection3
Total100

Grade Scale

Grade Points Grade Point Average (GPA)
A 94 – 100% 4.00
A- 90 – 93% 3.75
B+ 87 – 89% 3.50
B 84 – 86% 3.00
B- 80 – 83% 2.75
C+ 77 – 79% 2.50
C 74 – 76% 2.00
C- 70 – 73% 1.75
D 64 – 69% 1.00
F 00 – 63% 0.00

Schedule

Session Dates: 10/28/2026 – 12/18/2026

Week 1: Wednesday – Tuesday
Week 2: Wednesday – Tuesday
Week 3: Wednesday – Tuesday
Week 4: Wednesday – Tuesday
Week 5: Wednesday – Tuesday
Week 6: Wednesday – Tuesday
Week 7: Wednesday – Tuesday
Week 8: Wednesday – Friday

Week One: Energy Balance & Carbohydrate Metabolism

Weekly Learning Outcomes

  • Describe the major processes involved in carbohydrate metabolism and cellular energy production
  • Explain the relationships among glycolysis, the tricarboxylic acid (TCA) cycle, and the electron transport chain, and oxidative phosphorylation
  • Explain the role of ATP in supporting normal cellular function
  • Apply principles of energy metabolism
  • Explain biochemical processes related to health and disease

Lectures

  • Introduction to Biochemistry
  • Carbohydrates
  • Carbohydrate Metabolism (Part I)

Required Readings

  • Gropper Text: Chapter 3 – Carbohydrates; section 3.1-3.4
  • Coker JK, Moyne O, Rodionov DA, Zengler K. Carbohydrates great and small, from dietary fiber to sialic acids: how glycans influence the gut microbiome and affect human health. Gut Microbes. 2021;13(1):1. doi:10.1080/19490976.2020.1869502

Note: additional reading and videos can be found in the course

Quizzes

  • Week 1 Quiz

Discussions

  • Week 1 Discussion: Introductions!

Assignments

  • Syllabus Contract
  • Week 1 Assignment: Clinical Reasoning Presentation — “Energy Balance: Why Doesn’t More Calories Always Mean More Energy?” (5–8 minute recorded video)

 

Week Two: Blood Glucose Regulation & Carbohydrate Metabolism

Weekly Learning Outcomes

  • Describe the hormones involved in regulating blood glucose homeostasis
  • Explain how carbohydrate metabolism differs during the fed and fasting states
  • Interpret changes in glucose regulation associated with altered metabolism
  • Apply principles of carbohydrate metabolism to explain metabolic adaptations in health and disease

Lectures

  • Carbohydrate Metabolism (Part II)
  • Carbohydrate Metabolism (Part III)

Required Readings

  • Gropper Text: Chapter 3, Carbohydrates – Integrated Metabolism in Tissues; section 3.5-3.7
  • Kazeminasab F, Rafiee P, Miraghajani M, Santos HO, Symonds ME, Rosenkranz SK. The effects of acute bouts of exercise in fasted vs. fed states on glucose and lipid metabolism in healthy adults: a systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition ESPEN. 2025;66:320-331. doi:10.1016/j.clnesp.2025.02.002

Quizzes

  • Week 2 Quiz

Discussions

  • Week 2 Discussion: Insulin and Glucagon Regulation

Assignments

  • Week 2 Assignment: Clinical Reasoning Presentation

 

Week Three: Dietary Lipids & Lipoprotein Metabolism

Weekly Learning Outcomes

  • Describe the digestion, absorption, transport, and storage of dietary lipids
  • Explain the functions of lipoproteins in lipid metabolism
  • Explain biochemical processes associated with altered lipid metabolism
  • Apply principles of lipid metabolism to explain changes observed in health and disease

Lectures

  • Dietary Lipids (Part I)
  • Dietary Lipids (Part II)
  • Lipids – Lipoprotein Metabolism

Required Readings

  • Gropper Text: Chapter 5 – Lipids; section 5.1-5.6
  • Khalil A. Nutrition, lipoproteins and cardiovascular diseases. Nutrients. 2024;16(15):2530. doi:10.3390/nu16152530
  • Egalini F, Guardamagna O, Gaggero G, et al. The effects of omega 3 and omega 6 fatty acids on glucose metabolism: an updated review. Nutrients. 2023;15(12):2672. doi:10.3390/nu15122672

Quizzes

  • Week 3 Quiz

Discussions

  • Week 3 Discussion: Lipoproteins

Assignments

  • Week 3 Assignment: Clinical Reasoning Presentation

 

Week Four: Hepatic Lipid Metabolism & Ketone Bodies

Weekly Learning Outcomes

  • Describe the major pathways involved in hepatic lipid metabolism
  • Explain how alterations in energy metabolism influence lipid storage and utilization
  • Explain the physiological conditions associated with ketone body production
  • Analyze how dysregulated lipid metabolism contributes to metabolic disease

Lectures

  • Lipid Metabolism (Part I)
  • Lipid Metabolism (Part II)

Required Readings

  • Gropper Text: Chapter 5, Lipids; section 5.7-5.8
  • Szekeres Z, Toth K, Szabados E. The effects of SGLT2 inhibitors on lipid metabolism. Metabolites. 2021;11(2):87. doi:10.3390/metabo11020087
  • Carroll JH, Parkin T, Cross JH, et al. Drug-resistant epilepsy and ketogenic diet therapy — a qualitative study of families’ experiences. Seizure (London, England). 2024;118:137-147. doi:10.1016/j.seizure.2024.04.024

Quizzes

  • Week 4 Quiz

Discussions

  • Week 4 Discussion: Ketone Bodies

Assignments

  • Week 4 Assignment: Clinical Reasoning Presentation

 

Week Five: Protein & Amino Acid Metabolism

Weekly Learning Outcomes

  • Describe the digestion, absorption, and utilization of dietary proteins and amino acids
  • Explain the relationships among protein metabolism, nitrogen balance, and the urea cycle
  • Describe the biochemical processes involved in maintaining skeletal muscle
  • Analyze how alterations in protein metabolism contribute to changes in nutritional status

Lectures

  • Amino Acid Structure & Classification
  • Dietary Protein
  • Functional Roles of Proteins

Required Readings & Materials

  • Gropper Text: Chapter 6, Protein; section 6.1-6.4
  • Amino Acid Structure. Khan Academy.
  • Classification of Amino Acids. Khan Academy.

Quizzes

  • Week 5 Quiz

Discussions

  • Week 5 Discussion: The Urea Cycle and TCA Cycle

Assignments

  • Week 5 Assignment: Clinical Reasoning Presentation

 

Week Six: Protein Metabolism During Physiological Stress

Weekly Learning Outcomes

  • Describe the metabolic response to acute illness and inflammation
  • Explain the roles of amino acid catabolism and protein synthesis during physiological stress
  • Recognize the biochemical adaptations associated with the acute-phase response
  • Analyze how inflammation alters normal protein metabolism

Lectures

  • Protein Metabolism (Part I)
  • Protein Metabolism (Part II)
  • Protein Metabolism (Part III)

Required Readings

  • Gropper Text: Chapter 6, Protein; section 6.5-6.13
  • Overview of Amino Acid Metabolism. Khan Academy.

Quizzes

  • Week 6 Quiz

Discussions

  • Week 6 Discussion: The Life Cycle of an Amino Acid

Assignments

  • Week 6 Assignment: Clinical Reasoning Presentation

 

Week Seven: Vitamins & Minerals in Metabolism

Weekly Learning Outcomes

  • Describe the biochemical functions of vitamins and minerals in human metabolism
  • Explain how micronutrients support metabolic pathways and physiological function
  • Identify the metabolic consequences of vitamin and mineral deficiencies
  • Analyze how macro- and micronutrients interact to influence health and disease

Lectures

  • Introduction to Vitamins & Vitamin C
  • B Vitamins
  • Fat-Soluble Vitamins

Required Readings

  • Gropper Text: Chapter 9, Water-Soluble Vitamins
  • Gropper Text: Chapter 10, Fat-Soluble Vitamins

Quizzes

  • Week 7 Quiz

Discussions

  • Week 7 Discussion: The Metabolic Life Cycle of a Vitamin

Assignments

  • Week 7 Assignment: Clinical Reasoning Presentation

 

Week Eight: Minerals & Integrating Your Biochemistry Foundation

Weekly Learning Outcomes

  • Describe the relationships among carbohydrate, lipid, protein, vitamin, and mineral metabolism in maintaining normal physiological function
  • Explain how biochemical principles inform evidence-based nutrition practice
  • Analyze how advances in nutrition science, including pharmacological therapies, are supported by foundational biochemical concepts
  • Reflect on your growth in applying biochemical reasoning to health and disease and its role in your future development as a nutrition professional

Lectures

  • Minerals

Required Readings

  • Gropper Text: Chapter 11: Minerals

Discussions

  • Week 8 Discussion: GLP-1 Receptor Agonists — Bringing It All Together

Assignments

  • Week 8 Assignment: Course Reflection

Student Resources

Online Student Support

Your Student Support Specialist is a resource for you. Please don't hesitate to contact them for assistance, including, but not limited to course planning, current problems or issues in a course, technology concerns, or personal emergencies.

Questions? Visit the Student Support Applied Nutrition page

UNE Library

UNE Student Academic Success Center

The Student Academic Success Center (SASC) offers a range of services to support your academic achievement, including tutoring, writing support, test prep and studying strategies, learning style consultations, and many online resources. To make an appointment for tutoring, writing support, or a learning specialist consultation, go to une.tutortrac.com. To access our online resources, including links, guides, and video tutorials, please visit:

Information Technology Services (ITS)

Students should notify their student success team member and instructor in the event of a problem relating to a course. This notification should occur promptly and proactively to support timely resolution.

ITS Contact: Toll-Free Help Desk 24 hours/7 days per week

Phone: Mon-Fri: (207) 602-2487

After Hours/Weekends: 1-877-518-4673

Accommodations

Any student who would like to request, or ask any questions regarding, academic adjustments or accommodations must contact the Student Access Center at (207) 221-4438 or pcstudentaccess@une.edu. Student Access Center staff will evaluate the student's documentation and determine eligibility of accommodation(s) through the Student Access Center registration procedure.

Online Peer Support

Togetherall is a 24/7 communication and emotional support platform monitored by trained clinicians. It’s a safe place online to get things off your chest, have conversations, express yourself creatively, and learn how to manage your mental health. If sharing isn’t your thing, Togetherall has other tools and courses to help you look after yourself with plenty of resources to explore. Whether you’re struggling to cope, feeling low, or just need a place to talk, Togetherall can help you explore your feelings in a safe supportive environment. You can join Togetherall using your UNE email address.

Information Technology Services (ITS)

Students should notify their Student Support Specialist and instructor in the event of a problem relating to a course. This notification should occur promptly and proactively to support timely resolution.

ITS Contact: Toll-Free Help Desk 24 hours/7 days per week at 1-877-518-4673.

Career Ready Program

The College of Professional Studies supports its online students and alumni in their career journey!

The Career Ready Program provides tools and resources to help students explore and hone in on their career goals, search for jobs, create and improve professional documents, build professional network, learn interview skills, grow as a professional, and more. Come back often, at any time, as you move through your journey from career readiness as a student to career growth, satisfaction, and success as alumni.

Policies

AMA Writing Style Statement

In keeping with the requirements of the Journal of the Academy of Nutrition and Dietetics and the Journal of Nutrition Education and Behavior, the American Medical Association (AMA) Manual of Style, 11th edition is the required writing format for this course and is available at both UNE libraries under the title "AMA Manual." Additional support for academic writing and AMA format is provided throughout the coursework as well as at the UNE Portal for Online Students.

Online resources: AMA Style Guide

Turnitin Originality Check and Plagiarism Detection Tool

The College of Professional Studies uses Turnitin to help deter plagiarism and to foster the proper attribution of sources. Turnitin provides comparative reports for submitted assignments that reflect similarities in other written works. This can include, but is not limited to, previously submitted assignments, internet articles, research journals, and academic databases.

Make sure to cite your sources appropriately as well as use your own words in synthesizing information from published literature. Webinars and workshops, included early in your coursework, will help guide best practices in AMA citation and academic writing.

You can learn more about Turnitin in the guide on how to navigate your Similarity Report.

Generative AI Use Statement

Generative AI (GenAI) applications (e.g., ChatGPT, Claude, Gemini, CoPilot, and similar tools) are increasingly used in academic and professional workspaces. In the MSAN program, AI tools may be used in limited and transparent ways that support learning. They may not substitute for independent critical thinking, scientific reasoning, writing, analysis, or demonstration of mastery of course learning outcomes.

The use of AI in academic work falls under the MSAN Academic Integrity policy and must align with our commitment to honest, responsible, and professional scholarship. Additionally, the Academy of Nutrition and Dietetics Code of Ethics spotlights the value of integrity and the ethical principle of behaving in a trustworthy manner. 

Students should always be able to demonstrate the originality of submitted work if improper use of AI is suspected.

In situations where AI tools are used as a resource, students must:

  • Ensure that all submitted academic work demonstrates their own learning and mastery of course objectives.
  • Acknowledge every instance of AI use in-text at the point where it was used. AI use should not ONLY be listed in the References section. If a paper was run entirely through Grammarly or other AI-related tools, a general acknowledgment is needed.
  • Include a brief description of how the AI tool was used, followed by the AI tool name, model/version (if available), manufacturer/owner, and date used in parentheses. Students should consult the AI citation section of the AMA Style Guide for additional details.
  • Take full responsibility for the accuracy, interpretation, and conclusions presented in their work.
  • Critically evaluate AI output for errors, bias, and potential risks to vulnerable or underrepresented populations.
  • Follow any additional course or assignment-specific AI restrictions provided in assignment instructions.

Failure to acknowledge AI use in submitted work constitutes a violation of academic integrity and will be treated as plagiarism under the MSAN Academic Integrity Policy and Student Handbook.

Penalties for AI misuse will follow the MSAN program’s academic integrity escalation structure. A first offense of academic integrity will result in a zero on the assignment with an opportunity to resubmit resulting in a 20% reduction. A second instance of academic integrity will result in a zero for the assignment/s. A third instance may result in course failure and/or referral for program-level review, which may include dismissal from the program.

Late Policy

Assignments and Quizzes: Assignments or quizzes submitted after the due date and time will receive a deduction of 10% of the total possible grade for each day it is late. After three days, the assignment or quiz will not be accepted. No assignments or quizzes will be accepted after the course ends.

Discussion posts: If the initial post is submitted late, acceptance of the discussion board is at the discretion of the faculty. Any posts submitted after the end of the Discussion Board week will not be graded (does not apply to practicum).

Students are encouraged to make every effort ahead of time to contact their instructor and their student support specialist if they are not able to meet an assignment deadline. Arrangements for extenuating circumstances may be considered by faculty.

Technology Requirements

Please review the technical requirements for UNE Online Graduate Programs: Technical Requirements

Course Evaluation Policy

Course surveys are one of the most important tools that University of New England uses for evaluating the quality of your education, and for providing meaningful feedback to instructors on their teaching. In order to assure that the feedback is both comprehensive and precise, we need to receive it from each student for each course. Evaluation access is distributed via UNE email at the beginning of the last week of the course.

Attendance Policy

6- to 8-week courses: Students taking online graduate courses through the College of Professional Studies will be administratively dropped for non-participation if a graded assignment/discussion post is not submitted before Sunday at 11:59 pm ET of the first week of the term. Reinstatement is at the purview of the Dean's Office.

10+ -week courses: Students taking online graduate courses through the College of Professional Studies will be administratively dropped for non-participation if a graded assignment/discussion post is not submitted before Friday at 11:59 pm ET of the second week of the term. Reinstatement is at the purview of the Dean's Office.

Student Handbook Online - Policies and Procedures

The policies contained within this document apply to all students in the College of Professional Studies. It is each student's responsibility to know the contents of this handbook.

UNE Online Student Handbook

UNE Course Withdrawal

Please contact your Enrollment and Retention Counselor if you are considering dropping or withdrawing from a course. Tuition charges may still apply. Students are strongly urged to consult with Student Financial Services, as course withdrawals may affect financial aid or Veterans benefits.

Academic Integrity

The University of New England values academic integrity in all aspects of the educational experience. Academic dishonesty in any form undermines this standard and devalues the original contributions of others. It is the responsibility of all members of the University community to actively uphold the integrity of the academy; failure to act, for any reason, is not acceptable. For information about plagiarism and academic misconduct, please visit UNE Plagiarism Policies.

Academic dishonesty includes, but is not limited to the following:

  1. Cheating, copying, or the offering or receiving of unauthorized assistance or information.
  2. Fabrication or falsification of data, results, or sources for papers or reports.
  3. Action which destroys or alters the work of another student.
  4. Multiple submissions of the same paper or report for assignments in more than one course without permission of each instructor.
  5. Plagiarism, the appropriation of records, research, materials, ideas, or the language of other persons or writers and the submission of them as one's own.

Charges of academic dishonesty will be reviewed by the Program Director. Penalties for students found responsible for violations may depend upon the seriousness and circumstances of the violation, the degree of premeditation involved, and/or the student’s previous record of violations. Appeal of a decision may be made to the Dean whose decision will be final. Student appeals will take place through the grievance process outlined in the student handbook.